abstract：BACKGROUND:Habitual alcohol intake is known to aggravate the clinical outcome of hepatitis C virus (HCV)-related chronic liver diseases and to increase the risk of hepatocellular carcinoma. METHODS:To investigate the possible mechanism of these effects by alcohol, we examined 31 cases of HCV-related chronic liver dise...

journal_title：Journal of gastroenterology and hepatology

authors： Takahashi K,Takahashi T,Takahashi S,Watanabe K,Boku S,Matsui S,Arai F,Asakura H

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Experimental acute gastric ulcerations (EAGU) are healed very rapidly. This healing process has two steps; mucosal restitution and delayed repair. Adenosine 5'-triphosphate (ATP)-dependent potassium channels (K(ATP)) have a regulatory role in the gastrointestinal physiology. In the present study, th...

journal_title：Journal of gastroenterology and hepatology

authors： Rahgozar M,Pazokitoroudi H,Bakhtiarian A,Djahanguiri B

更新日期：2001-03-01 00:00:00

abstract：:A 22-year-old man visited our hospital (National Cancer Center Hospital East) complaining of fatigue and anorexia. A laboratory investigation demonstrated a biochemical 'picture' of obstructive jaundice. An abdominal CT showed a low density mass in the retropancreatic area with multiple enlarged periportal lymph nodes...

journal_title：Journal of gastroenterology and hepatology

authors： Miyamoto S,Furuse J,Maru Y,Tajiri H,Muto M,Yoshino M

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Hepatic steatosis is a histological characteristic in patients with chronic hepatitis C virus (HCV) infection. The aim of this study was to evaluate the prevalence of hepatic steatosis in Chinese patients with chronic hepatitis C, and to look for possible correlation with various histopathological c...

journal_title：Journal of gastroenterology and hepatology

authors： Hwang SJ,Luo JC,Chu CW,Lai CR,Lu CL,Tsay SH,Wu JC,Chang FY,Lee SD

更新日期：2001-02-01 00:00:00

abstract：:Following the development of tests for hepatitis C virus and hepatitis E virus infection, it became clear that there remained cases of hepatitis that were non-A-E. Such cases provided impetus for the search for additional hepatitis viruses and, by using molecular techniques, several candidates were identified. An ente...

journal_title：Journal of gastroenterology and hepatology

authors： Bowden S

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND AND AIMS:It is well known that endotoxemia, which is caused by a bacterial infection, can exacerbate acute pancreatitis, whereas pancreatitis-associated protein (PAP) has the ability to induce bacterial aggregation. Pancreatitis-associated protein is supposed to protect the tissue from infection during infla...

journal_title：Journal of gastroenterology and hepatology

authors： Wang X,Wang B,Wu J

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The classification of gastritis by using the revised Sydney system suggests that there are two types of Helicobacter pylori-related gastritis. The aim of the present study was to examine the risk factors that might be involved in the presence of either atrophic gastritis or intestinal metaplasia of ...

journal_title：Journal of gastroenterology and hepatology

authors： Tsukui T,Kashiwagi R,Sakane M,Tabata F,Akamatsu T,Wada K,Futagami S,Miyake K,Sueoka N,Hirakawa T,Kobayashi M,Fujimori T,Sakamoto C

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Saccharomyces cerevisiae may contribute to the pathophysiology of Crohn's disease. We determined serum anti-Saccharomyces cerevisiae antibody (ASCA) levels in patients with inflammatory bowel disease. METHODS AND RESULTS:Immunoglobulin G (IgG) ASCA was measured by using an ELISA in serum samples from 19 pat...

journal_title：Journal of gastroenterology and hepatology

authors： Oshitani N,Hato F,Matsumoto T,Jinno Y,Sawa Y,Hara J,Nakamura S,Seki S,Arakawa T,Kitano A,Kitagawa S,Kuroki T

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:It has been reported that cathepsin E (CTSE) is a non-secretory and intracellular aspartic proteinase found in the superficial epithelial cells of the stomach and that it is also expressed in pancreatic ductal adenocarcinoma. We evaluated the diagnostic value of CTSE in the pancreatic juice in the diagnosis ...

journal_title：Journal of gastroenterology and hepatology

authors： Uno K,Azuma T,Nakajima M,Yasuda K,Hayakumo T,Mukai H,Sakai T,Kawai K

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND AND AIMS:A relatively large number of patients with multiple myeloma have been reported to develop a secondary malignancy such as cancer of the breast, biliary system or bowel. METHODS:A retrospective study was perfomed in 734 patients with hematologic disease diagnosed at Nippon Medical School Hospital bet...

journal_title：Journal of gastroenterology and hepatology

authors： Kishida T,Yonezawa M,Shibata Y,Tanaka S,Shinozawa I,Hoshino T,Tatsuguchi A,Feng L,Sato J,Fujimori S,Yoshida Y,Sakamoto C,Kobayashi M

更新日期：2000-11-01 00:00:00

abstract：:The key issues that determine the decision between reusable versus disposable accessories are cost and functionality. In most health-care systems the availability and dissemination of endoscopic services relates directly to the resources (i.e. budget) of that system. Given the limitations of health-care budgets, acces...

journal_title：Journal of gastroenterology and hepatology

authors： Haber G

更新日期：2000-10-01 00:00:00

abstract：:Much has been achieved in Helicobacter pylori research, to the point that the growth of new knowledge is bound to slow down. However, expectations for further developments remain high. Knowledge about the characteristic organism and behaviour is already extensive. Particularly intriguing are the differences in genetic...

journal_title：Journal of gastroenterology and hepatology

authors： Tytgat G

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Troglitazone is a newly developed antidiabetic drug and is indicated to be useful for the treatment of patients with type II diabetes mellitus. Recently, however, it became clear that troglitazone could cause liver dysfunction in some patients. In addition, a relationship between the activation of t...

journal_title：Journal of gastroenterology and hepatology

authors： Jia DM,Tabaru A,Akiyama T,Abe S,Otsuki M

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Prostaglandin analogs have the pharmacologic effect of speeding up small intestinal transit (SIT). It remains unknown whether some gut peptides also mediate this enhancement. We studied the effect of misoprostol on rat SIT and looked at the role of vasoactive intestinal polypeptide (VIP) release dur...

journal_title：Journal of gastroenterology and hepatology

authors： Chang FY,Doong ML,Chen TS,Lee SD,Wang PS

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The bacterial beta-glucuronidase (bBG) can deconjugate conjugated bilirubin to form calcium bilirubinate gallstone. Yet, the role of the human biliary beta-glucuronidase (hBG) in the pathogenesis of pigment gallstone formation still remains unsolved. METHODS:Hepatic bile was collected from bile-duc...

journal_title：Journal of gastroenterology and hepatology

authors： Chen CY,Shiesh SC,Tsao HC,Lin XZ

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Nicotine administration is known to decrease lower oesophageal sphincter (LOS) pressure. Although a few studies have assessed the effect of tobacco on the LOS, the effect of acute and long-term oral tobacco use on oesophageal motility is not known. The study was designed to investigate the effect of...

journal_title：Journal of gastroenterology and hepatology

authors： Bhandarkar PV,Shah SK,Meshram M,Abraham P,Narayanan TS,Bhatia SJ

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Significant changes in hepatic haemodynamics occur after major hepatectomy, but the pathogenesis of this phenomenon is unclear. This study investigates the serum profile of prostaglandin and nitric oxide in the hepatic and systemic circulation before and after hepatectomy and the temporal relationsh...

journal_title：Journal of gastroenterology and hepatology

authors： Lai OF,Chow PK,Tan S,Song IC,Soo KC,Aw SE,Yu WK,Fook-Chong SM,Satchithanantham S,Chan ST

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND AND AIMS:The present study examined the effects of NS-398, a specific cyclo-oxygenase-2 inhibitor, on gastric mucosal cell kinetics and gastric wound healing following acid-induced injury. METHODS:Male Sprague-Dawley rats were fasted for 24 h and then 0.6 mol/L hydrochloric acid (HCl; 1 mL) was administered...

journal_title：Journal of gastroenterology and hepatology

authors： Sun WH,Tsuji S,Tsujii M,Gunawan ES,Sawaoka H,Kawai N,Iijima H,Kimura A,Kakiuchi Y,Yasumaru M,Sasaki Y,Kawano S,Hori M

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Biliary tract complications are frequent after orthotopic liver transplantation. Late biliary tract complications occurring after T-tube removal mostly include stones and strictures which may be associated with sepsis and worsening of the liver function. Endoscopic retrograde cholangiopancreatography (ERCP) ...

journal_title：Journal of gastroenterology and hepatology

authors： Mosca S,Militerno G,Guardascione MA,Amitrano L,Picciotto FP,Cuomo O

更新日期：2000-06-01 00:00:00

abstract：:The most frequent benign tumours of the liver include haemangioma, liver cell adenoma and focal nodular hyperplasia. Patients may undergo hepatic resection because of a preoperative diagnosis of malignancy or uncertainty in diagnosis despite an extensive work-up. ...

journal_title：Journal of gastroenterology and hepatology

authors： Chen MF

更新日期：2000-06-01 00:00:00

abstract：:The preferred treatment for patients with chronic hepatitis C, either treatment-naive, relapsers or nonresponders to IFN monotherapy, is now IFN-ribavirin combination treatment. The adverse effects of IFN are well established and familiar to hepatologists all over the world. More than 25,000 patients worldwide have be...

journal_title：Journal of gastroenterology and hepatology

authors： Chutaputti A

更新日期：2000-05-01 00:00:00

abstract：:To study the short- and long-term outcomes of acute hepatitis C, three groups of patients were enrolled. Of 26 patients with acute hepatitis C, 18 (69%) maintained HCV viraemia and 8 had cleared virus naturally at 12 months after the onset. Normalization of ALT was seen in all 8 patients with acute resolving hepatitis...

journal_title：Journal of gastroenterology and hepatology

authors： Tanaka E,Kiyosawa K

更新日期：2000-05-01 00:00:00

abstract：:Interferon-alpha (IFN-alpha) has been the only approved agent for the treatment of chronic hepatitis B in most countries, but this is rapidly changing. It is expensive, associated with frequent and unpleasant side effects, has limited efficacy and is ineffective in subjects with no/mild liver necro-inflammation. Loss ...

journal_title：Journal of gastroenterology and hepatology

authors： Guan R

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Poly-adenosine diphosphate (ADP)-ribosylation, catalysed by poly(ADP-ribose) polymerase (PARP), is a post-translational modification of nuclear proteins and is involved in a wide range of biological processes including DNA repair, cell proliferation and malignant transformation. Alteration of this reaction i...

journal_title：Journal of gastroenterology and hepatology

authors： Nomura F,Yaguchi M,Togawa A,Miyazaki M,Isobe K,Miyake M,Noda M,Nakai T

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3 are diagnostic of Wegener's granulomatosis, but ANCA occur also in patients with other inflammatory disorders, such as ulcerative colitis, primary sclerosing cholangitis (PSC) and autoimmune hepatitis. As their predictive value for autoimmune...

journal_title：Journal of gastroenterology and hepatology

authors： Lindgren S,Nilsson S,Nässberger L,Verbaan H,Wieslander J

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:It has been suggested that gastric mucosal injury induced by Helicobacter pylori infection is mediated by interleukin-8 (IL-8). METHODS:We studied the effect of plaunotol, a drug extracted from the Plau-noi tree of Thailand, and reported it to be effective in the treatment of ulcers, of IL-8 secretion induc...

journal_title：Journal of gastroenterology and hepatology

authors： Takagi A,Koga Y,Aiba Y,Kabir AM,Watanabe S,Ohta-Tada U,Osaki T,Kamiya S,Miwa T

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The objective of this study was to describe the prevalence of pathogenic microorganisms in asymptomatic individuals in a community study in Melbourne, Australia. METHODS:The study population was a subset of 2803 individuals participating in the Water Quality Study; a community based randomized tria...

journal_title：Journal of gastroenterology and hepatology

authors： Hellard ME,Sinclair MI,Hogg GG,Fairley CK

更新日期：2000-03-01 00:00:00

abstract：:Apoptosis, a programmed cell death, was ignored, just like Helicobacter pylori, only to reappear recently. However, the number of current publications dealing with apoptosis or H. pylori has increased exponentially. Although gastric epithelial apoptosis is a programmed physiological event in the superficial aspect of ...

journal_title：Journal of gastroenterology and hepatology

authors： Suzuki H,Ishii H

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:We previously developed a new diagnostic method for Helicobacter pylori infection and called it the endoscopic [13C]-urea breath test (EUBT). Here we evaluate the relationship between the EUBT results and the histological findings. METHODS:The EUBT was performed on 137 patients with gastroduodenal diseases....

journal_title：Journal of gastroenterology and hepatology

authors： Suto H,Azuma T,Ito S,Ito Y,Miyaji H,Yamazaki Y,Kohli Y,Kuriyama M

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:The expressions of CD95 (Fas/APO-1) and Bcl-2 are determinants of apoptosis in normal lymphocytes, and abnormalities in their expressions might contribute to the induction of autoimmunity. In this study, we examined the expressions of CD95 and Bcl-2 on freshly isolated T and B cells from patients with autoim...

journal_title：Journal of gastroenterology and hepatology

authors： Ogawa S,Sakaguchi K,Takaki A,Shiraga K,Sawayama T,Mouri H,Miyashita M,Koide N,Tsuji T

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:The objective of three-dimensional (3-D) endoscopic ultrasonography (EUS) is to recognize lesions stereoscopically. METHODS AND RESULTS:We investigated a total of 43 lesions in the upper gastrointestinal (GI) tract by regenerating 3-D images in eight cases of oesophageal cancer, two cases of oesophageal sub...

journal_title：Journal of gastroenterology and hepatology

authors： Tokiyama H,Yanai H,Nakamura H,Takeo Y,Yoshida T,Okita K

更新日期：1999-12-01 00:00:00

abstract：:Although the advancement of molecular oncology in gastric cancer lags behind that of colorectal cancer, the rapid developments witnessed in recent years have improved our understanding of the carcinogenesis, aetiology, progression and metastasis of gastric cancer. The different molecular genetic alterations in intesti...

journal_title：Journal of gastroenterology and hepatology

authors： Chan AO,Luk JM,Hui WM,Lam SK

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Patients with cirrhosis exhibit splanchnic, peripheral and pulmonary vasodilation, which are thought to play a role in increasing portal pressure, promoting sodium retention and determining arterial hypoxaemia. The present study investigated whether these abnormalities are influenced by portal hypertension o...

journal_title：Journal of gastroenterology and hepatology

authors： Luca A,García-Pagán JC,de Lacy AM,Escorsell A,Feu F,Visa J,Bosch J,Rodés J

更新日期：1999-11-01 00:00:00

abstract：:Helicobacter pylori infection may not be the primary cause of duodenal ulceration in cases not associated with non-steroidal anti-inflammatory drugs, but may be a secondary complication. In developing countries with a uniformly high prevalence of H. pylori infection there are marked regional differences in the prevale...

journal_title：Journal of gastroenterology and hepatology

authors： Tovey FI,Hobsley M

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the potential role of three-dimensional (3-D) conformal radiotherapy (RT) in treatment of unresectable hepatocellular carcinoma (HCC). METHODS:Thirteen patients were included in this study, which was conducted between 1993 and 1996. Nine patients (group A) were tre...

journal_title：Journal of gastroenterology and hepatology

authors： Cheng SH,Lin YM,Chuang VP,Yang PS,Cheng JC,Huang AT,Sung JL

更新日期：1999-10-01 00:00:00

abstract：:Gilbert's syndrome, an hereditary, chronic, mild, unconjugated hyperbilirubinaemia resulting from impaired hepatic bilirubin clearance and otherwise normal liver function, is arguably the most common syndrome known in humans. Recent molecular genetic studies have determined that the clinical phenotype can be described...

journal_title：Journal of gastroenterology and hepatology

authors： Burchell B,Hume R

更新日期：1999-10-01 00:00:00

abstract：:Complete duplication of the entire large bowel with partial ileal involvement is very rare and diagnosis can often be difficult as illustrated by this case report. We also review the other clinical associations of this rare condition and briefly discuss the embryology of duplications of the gastrointestinal tract. ...

journal_title：Journal of gastroenterology and hepatology

authors： Jimenez SG,Oliver MR,Stokes KB,Morreau PN,Chow CW

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:This study aimed to describe the clinical features, manometric findings, prevalence and incidence of achalasia in Singapore. METHODS:A total of 615 new patients referred for oesophageal manometry between 1989 and 1996 were examined prospectively. Twenty-four men and 25 women fulfilled the manometric and cli...

journal_title：Journal of gastroenterology and hepatology

authors： Ho KY,Tay HH,Kang JY

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Cyanoacrylate injection is highly effective and is regarded as the treatment of choice in bleeding gastric varices in Europe, but intravenous injection of cyanoacrylate is not allowed in the USA and Japan because it may cause embolisms in other organs. Accordingly, we developed a new endoscopic combined trea...

journal_title：Journal of gastroenterology and hepatology

authors： Yoshida T,Harada T,Shigemitsu T,Takeo Y,Miyazaki S,Okita K

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:The liver is the major iron storage organ in the body and, as a result, total body iron stores closely regulate hepatocyte iron uptake, storage and release. Transferrin, transferrin receptor and ferritin facilitate these processes. METHODS:Expression of the three proteins was localized by immunohistochemist...

journal_title：Journal of gastroenterology and hepatology

authors： Basclain KA,Jeffrey GP

更新日期：1999-07-01 00:00:00